| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP6V0A1 (60-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATP6V0A1 |
| Gene ID: |
535 |
| Uniprot ID: |
VPP1_HUMAN |
| Immunogen Region: |
60-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ATP6V0A1 (NP_001123493.1). |
| Immunogen Sequence: |
EMDRKLRFVEKEIRKANIPI MDTGENPEVPFPRDMIDLEA NFEKIENELKEINTNQEALK RNFLELTELKFILRKTQQFF DEMADPDLLEESSSLLEPSE MGRGTPLRLGFVAGVINRER IPTFERMLWRVCRGNVFLRQ AEIENPLEDPVTGDYVHKSV FIIFFQGDQLKNRVKKICEG FRASLYPCPETPQERKEMAS GVNTRIDDLQMVLNQTEDHR QRVLQAAAKNIRVWFIKVR |
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment. Required for assembly and activity of the vacuolar ATPase. Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons. |
| Protein Name | V-Type Proton Atpase 116 Kda Subunit A 1V-Atpase 116 Kda Subunit A 1Clathrin-Coated Vesicle/Synaptic Vesicle Proton Pump 116 Kda SubunitVacuolar Adenosine Triphosphatase Subunit Ac116Vacuolar Proton Pump Subunit 1Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 1 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-6798695Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-983712 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembraneMulti-Pass Membrane ProteinSecretory VesicleSynaptic Vesicle MembraneMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-V-Type Proton Atpase 116 Kda Subunit A 1 antibodyAnti-V-Atpase 116 Kda Subunit A 1 antibodyAnti-Clathrin-Coated Vesicle/Synaptic Vesicle Proton Pump 116 Kda Subunit antibodyAnti-Vacuolar Adenosine Triphosphatase Subunit Ac116 antibodyAnti-Vacuolar Proton Pump Subunit 1 antibodyAnti-Vacuolar Proton Translocating Atpase 116 Kda Subunit A Isoform 1 antibodyAnti-ATP6V0A1 antibodyAnti-ATP6N1 antibodyAnti-ATP6N1A antibodyAnti-VPP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
