Anti-ATOH7 antibody (47-152) (STJ29412)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ATOH7 (47-152) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATOH7 |
| Gene ID | 220202 |
| Uniprot ID | ATOH7_HUMAN |
| Immunogen Region | 47-152 |
| Immunogen Sequence | ARERRRMQGLNTAFDRLRRV VPQWGQDKKLSKYETLQMAL SYIMALTRILAEAERFGSER DWVGLHCEHFGRDHYLPFPG AKLPGESELYSQRLFGFQPE PFQMAT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 47-152 of human ATOH7 (NP_660161.1). |
Additional Info
| Function | Transcription factor that binds to DNA at the consensus sequence 5'-CAGGCTG-3'. Dimerization with TCF3 isoform E47 may be required in certain situations. Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes. Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract. Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription. Required for retinal circadian rhythm photoentrainment. Plays a role in brainstem auditory signaling and binaural processing. |
| Protein Name | Transcription Factor Atoh7Atonal Bhlh Transcription Factor 7Class A Basic Helix-Loop-Helix Protein 13Bhlha13Protein Atonal Homolog 7 |
| Database Links | |
| Cellular Localisation | NucleusPerikaryonCell ProjectionAxon |
| Alternative Antibody Names | Anti-Transcription Factor Atoh7 antibodyAnti-Atonal Bhlh Transcription Factor 7 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 13 antibodyAnti-Bhlha13 antibodyAnti-Protein Atonal Homolog 7 antibodyAnti-ATOH7 antibodyAnti-ATH5 antibodyAnti-BHLHA13 antibody |
Information sourced from Uniprot.org