| Host: | Rabbit |
| Applications: | WB/IHC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein Asteroid Homolog 1 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 0.78 mg/mL |
| Dilution Range: | WB 1:500-1:2000, IHC 1:50-1:300 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | ASTE1 |
| Gene ID: | 28990 |
| Uniprot ID: | ASTE1_HUMAN |
| Immunogen: | Fusion protein of human ASTE1 |
| Function | Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ). |
| Protein Name | Single-Strand Dna Endonuclease Aste1Protein Asteroid Homolog 1 |
| Alternative Antibody Names | Anti-Single-Strand Dna Endonuclease Aste1 antibodyAnti-Protein Asteroid Homolog 1 antibodyAnti-ASTE1 antibodyAnti-HT001 antibody |
Information sourced from Uniprot.org