Anti-ASTE1 antibody (STJA0004442)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human ASTE1
General Information
| Short Description | Rabbit polyclonal anti-Protein Asteroid Homolog 1 for use in WB, IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ASTE1 |
| Gene ID | 28990 |
| Uniprot ID | ASTE1_HUMAN |
| Immunogen | Fusion protein of human ASTE1 |
Additional Info
| Function | Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ). |
| Protein Name | Single-Strand Dna Endonuclease Aste1Protein Asteroid Homolog 1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Single-Strand Dna Endonuclease Aste1 antibodyAnti-Protein Asteroid Homolog 1 antibodyAnti-ASTE1 antibodyAnti-HT001 antibody |
Information sourced from Uniprot.org