Anti-ASIC5 antibody (412-462 aa) (STJ193822)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ASIC5 at the amino acid range 412-462
General Information
| Short Description | Rabbit polyclonal anti-Acid-sensing ion channel 5 channel (412-462 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASIC5 |
| Gene ID | 51802 |
| Uniprot ID | ASIC5_HUMAN |
| Immunogen | Synthesized peptide derived from the human ASIC5 at the amino acid range 412-462 |
| Immunogen Region | 412-462 aa |
| Specificity | This antibody detects endogenous levels of ASIC5 at Human/Mouse/Rat |
Additional Info
| Function | Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts. Displays high selectivity for sodium ions but can also permit the permeation of other cations (Probable). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids. As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance. |
| Protein Name | Bile Acid-Sensitive Ion ChannelBasicAcid-Sensing Ion Channel Subunit Family Member 5Amiloride-Sensitive Cation Channel 5 - IntestinalHuman Intestine Na(+ ChannelHinac |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Bile Acid-Sensitive Ion Channel antibodyAnti-Basic antibodyAnti-Acid-Sensing Ion Channel Subunit Family Member 5 antibodyAnti-Amiloride-Sensitive Cation Channel 5 - Intestinal antibodyAnti-Human Intestine Na(+ Channel antibodyAnti-Hinac antibodyAnti-ASIC5 antibodyAnti-ACCN5 antibody |
Information sourced from Uniprot.org