Anti-ASIC5 antibody (2-50 aa) (STJ13100716)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 2-50 of mouse ASIC5 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ASIC5 (2-50 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Asic5 |
| Gene ID | 58170 |
| Uniprot ID | ASIC5_MOUSE |
| Immunogen | A synthetic peptide from aa region 2-50 of mouse ASIC5 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 2-50 aa |
| Specificity | Specific for ASIC5. |
Additional Info
| Function | Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts. Displays high selectivity for sodium ions but can also permit the permeation of other cations. The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids. As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance. |
| Protein Name | Bile Acid-Sensitive Ion ChannelBasicAcid-Sensing Ion Channel Subunit Family Member 5Amiloride-Sensitive Cation Channel 5Brain-Liver-Intestine Amiloride-Sensitive Na(+ ChannelBlinac |
| Database Links | Reactome: R-MMU-2672351 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Bile Acid-Sensitive Ion Channel antibodyAnti-Basic antibodyAnti-Acid-Sensing Ion Channel Subunit Family Member 5 antibodyAnti-Amiloride-Sensitive Cation Channel 5 antibodyAnti-Brain-Liver-Intestine Amiloride-Sensitive Na(+ Channel antibodyAnti-Blinac antibodyAnti-Asic5 antibodyAnti-Accn5 antibody |
Information sourced from Uniprot.org