Anti-ASIC5 antibody (2-50 aa) (STJ13100716)

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STJ13100716-100
€387.00
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-ASIC5 (2-50 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Asic5
Gene ID: 58170
Uniprot ID: ASIC5_MOUSE
Immunogen Region: 2-50 aa
Specificity: Specific for ASIC5.
Immunogen: A synthetic peptide from aa region 2-50 of mouse ASIC5 conjugated to blue carrier protein was used as the antigen.
Function Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts. Displays high selectivity for sodium ions but can also permit the permeation of other cations. The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids. As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance.
Protein Name Bile Acid-Sensitive Ion Channel
Basic
Acid-Sensing Ion Channel Subunit Family Member 5
Amiloride-Sensitive Cation Channel 5
Brain-Liver-Intestine Amiloride-Sensitive Na(+ Channel
Blinac
Database Links Reactome: R-MMU-2672351
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Alternative Antibody Names Anti-Bile Acid-Sensitive Ion Channel antibody
Anti-Basic antibody
Anti-Acid-Sensing Ion Channel Subunit Family Member 5 antibody
Anti-Amiloride-Sensitive Cation Channel 5 antibody
Anti-Brain-Liver-Intestine Amiloride-Sensitive Na(+ Channel antibody
Anti-Blinac antibody
Anti-Asic5 antibody
Anti-Accn5 antibody

Information sourced from Uniprot.org