| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASCC3 (1-111) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASCC3 |
| Gene ID: |
10973 |
| Uniprot ID: |
ASCC3_HUMAN |
| Immunogen Region: |
1-111 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ASCC3 (NP_071374.1). |
| Immunogen Sequence: |
MALPRLTGALRSFSNVTKQD NYNEEVADLKIKRSKLHEQV LDLGLTWKKIIKFLNEKLEK SKMQSINEDLKDILHAAKQI EVNCPFQKRRLDGKEEDEKM SRASDRFRGLR |
| Tissue Specificity | Ubiquitous. |
| Function | ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 3Asc-1 Complex Subunit P200Asc1p200Helicase - Atp Binding 1Trip4 Complex Subunit P200 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmCytosolColocalizes With Alkbh3 And Ascc2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 3 antibodyAnti-Asc-1 Complex Subunit P200 antibodyAnti-Asc1p200 antibodyAnti-Helicase - Atp Binding 1 antibodyAnti-Trip4 Complex Subunit P200 antibodyAnti-ASCC3 antibodyAnti-HELIC1 antibodyAnti-RQT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
