Anti-ASCC1 antibody (1-180) (STJ118277)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ASCC1 (1-180) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASCC1 |
| Gene ID | 51008 |
| Uniprot ID | ASCC1_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MEVLRPQLIRIDGRNYRKNP VQEQTYQHEEDEEDFYQGSM ECADEPCDAYEVEQTPQGFR STLRAPSLLYKHIVGKRGDT RKKIEMETKTSISIPKPGQD GEIVITGQHRNGVISARTRI DVLLDTFRRKQPFTHFLAFF LNEVEVQEGFLRFQEEVLAK CSMDHGVDSSIFQNPKKLHL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ASCC1 (NP_001185727.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 1Asc-1 Complex Subunit P50Trip4 Complex Subunit P50 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With Prpf8 In Nuclear Speckles In The Absence Of Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 1 antibodyAnti-Asc-1 Complex Subunit P50 antibodyAnti-Trip4 Complex Subunit P50 antibodyAnti-ASCC1 antibodyAnti-CGI-18 antibody |
Information sourced from Uniprot.org