| Short Description : | Rabbit polyclonal ASCC1 (1-180) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASCC1 |
| Gene ID: | 51008 |
| Uniprot ID: | ASCC1_HUMAN |
| Immunogen Region: | 1-180 |
| Immunogen Sequence: | MEVLRPQLIRIDGRNYRKNP VQEQTYQHEEDEEDFYQGSM ECADEPCDAYEVEQTPQGFR STLRAPSLLYKHIVGKRGDT RKKIEMETKTSISIPKPGQD GEIVITGQHRNGVISARTRI DVLLDTFRRKQPFTHFLAFF LNEVEVQEGFLRFQEEVLAK CSMDHGVDSSIFQNPKKLHL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ASCC1 (NP_001185727.1). |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 1Asc-1 Complex Subunit P50Trip4 Complex Subunit P50 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With Prpf8 In Nuclear Speckles In The Absence Of Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 1 antibodyAnti-Asc-1 Complex Subunit P50 antibodyAnti-Trip4 Complex Subunit P50 antibodyAnti-ASCC1 antibodyAnti-CGI-18 antibody |
Information sourced from Uniprot.org
