| Short Description : | Rabbit polyclonal ARPC2 (1-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC2 |
| Gene ID: | 10109 |
| Uniprot ID: | ARPC2_HUMAN |
| Immunogen Region: | 1-300 |
| Immunogen Sequence: | MILLEVNNRIIEETLALKFE NAAAGNKPEAVEVTFADFDG VLYHISNPNGDKTKVMVSIS LKFYKELQAHGADELLKRVY GSFLVNPESGYNVSLLYDLE NLPASKDSIVHQAGMLKRNC FASVFEKYFQFQEEGKEGEN RAVIHYRDDETMYVESKKDR VTVVFSTVFKDDDDVVIGKV FMQEFKEGRRASHTAPQVLF SHREPPLELKDTDAAVGDNI GYITFVLFPRHTNASARDN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ARPC2 (NP_690601.1). |
| Function | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 2Arp2/3 Complex 34 Kda SubunitP34-Arc |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-3928662Reactome: R-HSA-5663213Reactome: R-HSA-8856828Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionSynapseSynaptosomeNucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 2 antibodyAnti-Arp2/3 Complex 34 Kda Subunit antibodyAnti-P34-Arc antibodyAnti-ARPC2 antibodyAnti-ARC34 antibodyAnti-PRO2446 antibody |
Information sourced from Uniprot.org
