Anti-ARL6IP1 antibody (STJA0008940)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ARMER
General Information
| Short Description | Rabbit polyclonal anti-ADP-ribosylation factor-like protein 6-interacting protein 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARL6IP1 |
| Gene ID | 23204 |
| Uniprot ID | AR6P1_HUMAN |
| Immunogen | Synthesized peptide derived from human ARMER |
| Specificity | This antibody detects endogenous levels of ARMER at Human, Mouse |
Additional Info
| Function | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1Arl-6-Interacting Protein 1Aip-1Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum |
| Database Links | |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic ReticulumPredominantly Localized To Intracytoplasmic MembranesPreferentially Localizes At The Er Tubules And The Edge Of The Er SheetsBoth Of Which Are Characterized By A High Membrane Curvature |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibodyAnti-Arl-6-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibodyAnti-ARL6IP1 antibodyAnti-ARL6IP antibodyAnti-ARMER antibodyAnti-KIAA0069 antibody |
Information sourced from Uniprot.org