| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADP-ribosylation factor-like protein 6-interacting protein 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARL6IP1 |
| Gene ID: |
23204 |
| Uniprot ID: |
AR6P1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ARMER at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human ARMER |
| Function | Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1Arl-6-Interacting Protein 1Aip-1Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneEndoplasmic ReticulumPredominantly Localized To Intracytoplasmic MembranesPreferentially Localizes At The Er Tubules And The Edge Of The Er SheetsBoth Of Which Are Characterized By A High Membrane Curvature |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibodyAnti-Arl-6-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibodyAnti-ARL6IP1 antibodyAnti-ARL6IP antibodyAnti-ARMER antibodyAnti-KIAA0069 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ARL6IP1 knockout (KO) 293T cells, using [KO Validated] ARL6IP1 Rabbit polyclonal antibody (STJ11100871) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89805/358272/STJ11100871_1__58128.1713122615.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ARL6IP1 knockout (KO) 293T cells, using [KO Validated] ARL6IP1 Rabbit polyclonal antibody (STJ11100871) at 1:5000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
