Anti-ARL3 antibody (109-159) (STJA0006599)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ARL3 AA range: 109-159
General Information
| Short Description | Rabbit polyclonal anti-ADP-ribosylation factor-like protein 3 (109-159) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARL3 |
| Gene ID | 403 |
| Uniprot ID | ARL3_HUMAN |
| Immunogen | Synthesized peptide derived from human ARL3 AA range: 109-159 |
| Immunogen Region | 109-159 |
| Specificity | This antibody detects endogenous levels of human ARL3 |
Additional Info
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 3 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonSpindleNucleusMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumDetected Predominantly In The Photoreceptor Connecting CiliumPresent On The Mitotic SpindleCentrosome-Associated Throughout The Cell CycleNot Detected To Interphase Microtubules |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 3 antibodyAnti-ARL3 antibodyAnti-ARFL3 antibody |
Information sourced from Uniprot.org