| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADP-ribosylation factor-like protein 3 (109-159) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARL3 |
| Gene ID: |
403 |
| Uniprot ID: |
ARL3_HUMAN |
| Immunogen Region: |
109-159 |
| Specificity: |
This antibody detects endogenous levels of human ARL3 |
| Immunogen: |
Synthesized peptide derived from human ARL3 AA range: 109-159 |
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 3 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonSpindleNucleusMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumDetected Predominantly In The Photoreceptor Connecting CiliumPresent On The Mitotic SpindleCentrosome-Associated Throughout The Cell CycleNot Detected To Interphase Microtubules |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 3 antibodyAnti-ARL3 antibodyAnti-ARFL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
