Anti-ARL2 antibody (1-184) (STJ22683)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ARL2 (1-184) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARL2 |
| Gene ID | 402 |
| Uniprot ID | ARL2_HUMAN |
| Immunogen Region | 1-184 |
| Immunogen Sequence | MGLLTILKKMKQKERELRLL MLGLDNAGKTTILKKFNGED IDTISPTLGFNIKTLEHRGF KLNIWDVGGQKSLRSYWRNY FESTDGLIWVVDSADRQRMQ DCQRELQSLLVEERLAGATL LIFANKQDLPGALSSNAIRE VLELDSIRSHHWCIQGCSAV TGENLLPGIDWLLDDISSRI FTAD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human ARL2 (NP_001658.2). |
Additional Info
| Post Translational Modifications | Not N-myristoylated. |
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Also regulates mitochondrial integrity and function. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 2 |
| Database Links | Reactome: R-HSA-389977Reactome: R-HSA-83936Reactome: R-HSA-9648002 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusThe Complex Formed With Arl2bpArl2 And Slc25a6 Is Expressed In MitochondriaArl2 And Slc25a4 Is Expressed In MitochondriaNot Detected In The GolgiNucleus And On The Mitotic SpindleCentrosome-Associated Throughout The Cell CycleNot Detected To Interphase Microtubules |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 2 antibodyAnti-ARL2 antibody |
Information sourced from Uniprot.org