Anti-ARL13B antibody (1-240) (STJ27176)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ARL13B (1-240) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARL13B |
| Gene ID | 200894 |
| Uniprot ID | AR13B_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MFSLMASCCGWFKRWREPVR KVTLLMVGLDNAGKTATAKG IQGEYPEDVAPTVGFSKINL RQGKFEVTIFDLGGGIRIRG IWKNYYAESYGVIFVVDSSD EERMEETKEAMSEMLRHPRI SGKPILVLANKQDKEGALGE ADVIECLSLEKLVNEHKCLC QIEPCSAISGYGKKIDKSIK KGLYWLLHVIARDFDALNER IQKETTEQRALEEQEKQERA ERVRKLREERKQNEQEQAE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ARL13B (NP_878899.1). |
Additional Info
| Tissue Specificity | Expressed in the developing brain. |
| Post Translational Modifications | Sumoylation is required for PKD2 entry into cilium. |
| Function | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit.the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. May regulate ARF6- and RAB22A-dependent endocytic recycling traffic. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 13bAdp-Ribosylation Factor-Like Protein 2-Like 1Arl2-Like Protein 1 |
| Database Links | Reactome: R-HSA-5624958Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9646399 |
| Cellular Localisation | Cell ProjectionCilium MembraneLipid-AnchorCiliumCell MembraneCytoplasmCytoskeletonAssociates With The Cilium Membrane Via PalmitoylationLocalizes To Proximal Ciliary MembranesTo An Inversin-Like Subciliary Membrane CompartmentExcluding The Transition ZoneColocalizes With Microtubules |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 13b antibodyAnti-Adp-Ribosylation Factor-Like Protein 2-Like 1 antibodyAnti-Arl2-Like Protein 1 antibodyAnti-ARL13B antibodyAnti-ARL2L1 antibody |
Information sourced from Uniprot.org