| Host: |
Rabbit |
| Applications: |
IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 Ubiquitin-Protein Ligase Arih2 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: |
Antigen affinity purification |
| Concentration: |
1.2 mg/mL |
| Dilution Range: |
IHC 1:50-1:300 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Widely expressed with higher expression in granulocytes. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination promotes proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Arih2Ari-2Protein Ariadne-2 HomologRing-Type E3 Ubiquitin Transferase Arih2Triad1 Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Arih2 antibodyAnti-Ari-2 antibodyAnti-Protein Ariadne-2 Homolog antibodyAnti-Ring-Type E3 Ubiquitin Transferase Arih2 antibodyAnti-Triad1 Protein antibodyAnti-ARIH2 antibodyAnti-ARI2 antibodyAnti-TRIAD1 antibodyAnti-HT005 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
