Anti-ARIH2 antibody (STJA0004351)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human ARIH2
General Information
| Short Description | Rabbit polyclonal anti-E3 Ubiquitin-Protein Ligase Arih2 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ARIH2 |
| Gene ID | 10425 |
| Uniprot ID | ARI2_HUMAN |
| Immunogen | Fusion protein of human ARIH2 |
Additional Info
| Tissue Specificity | Widely expressed with higher expression in granulocytes. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination promotes proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex. Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB. Promotes ubiquitination of DCUN1D1. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. |
| Protein Name | E3 Ubiquitin-Protein Ligase Arih2Ari-2Protein Ariadne-2 HomologTriad1 Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Arih2 antibodyAnti-Ari-2 antibodyAnti-Protein Ariadne-2 Homolog antibodyAnti-Triad1 Protein antibodyAnti-ARIH2 antibodyAnti-ARI2 antibodyAnti-TRIAD1 antibodyAnti-HT005 antibody |
Information sourced from Uniprot.org