Anti-ARHGEF26 antibody (STJA0008143)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SGEF
General Information
| Short Description | Rabbit polyclonal anti-Rho guanine nucleotide exchange factor 26 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF26 |
| Gene ID | 26084 |
| Uniprot ID | ARHGQ_HUMAN |
| Immunogen | Synthesized peptide derived from human SGEF |
| Specificity | This antibody detects endogenous levels of SGEF at Human |
Additional Info
| Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 26Sh3 Domain-Containing Guanine Exchange Factor |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-9013148Reactome: R-HSA-9013408 |
| Cellular Localisation | Cell ProjectionRuffle |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 26 antibodyAnti-Sh3 Domain-Containing Guanine Exchange Factor antibodyAnti-ARHGEF26 antibodyAnti-SGEF antibodyAnti-HMFN1864 antibody |
Information sourced from Uniprot.org