| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 26 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARHGEF26 |
| Gene ID: | 26084 |
| Uniprot ID: | ARHGQ_HUMAN |
| Specificity: | This antibody detects endogenous levels of SGEF at Human |
| Immunogen: | Synthesized peptide derived from human SGEF |
| Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 26Sh3 Domain-Containing Guanine Exchange Factor |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-9013148Reactome: R-HSA-9013408 |
| Cellular Localisation | Cell ProjectionRuffle |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 26 antibodyAnti-Sh3 Domain-Containing Guanine Exchange Factor antibodyAnti-ARHGEF26 antibodyAnti-SGEF antibodyAnti-HMFN1864 antibody |
Information sourced from Uniprot.org
