| Short Description : | Rabbit polyclonal anti-Apoptosis-resistant E3 ubiquitin protein ligase 1 (354-404 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:1000-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AREL1 |
| Gene ID: | 9870 |
| Uniprot ID: | AREL1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human K0317 at the amino acid range 354-404 |
| Immunogen Region: | 354-404 aa |
| Specificity: | This antibody detects endogenous levels of human K0317 |
| Function | E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome. |
| Protein Name | Apoptosis-Resistant E3 Ubiquitin Protein Ligase 1Apoptosis-Resistant Hect-Type E3 Ubiquitin Transferase 1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Apoptosis-Resistant E3 Ubiquitin Protein Ligase 1 antibodyAnti-Apoptosis-Resistant Hect-Type E3 Ubiquitin Transferase 1 antibodyAnti-AREL1 antibodyAnti-KIAA0317 antibody |
Information sourced from Uniprot.org
