| Host: |
Rabbit |
| Applications: |
IHC-P/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IHC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
AQP3 |
| Gene ID: |
360 |
| Uniprot ID: |
AQP3_HUMAN |
| Immunogen Region: |
193-292 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 193-292 of human AQP3 (NP_004916.1). |
| Immunogen Sequence: |
FTVGLVVLVIGTSMGFNSGY AVNPARDFGPRLFTALAGWG SAVFTTGQHWWWVPIVSPLL GSIAGVFVYQLMIGCHLEQP PPSNEEENVKLAHVKHKEQI |
| Tissue Specificity | Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance. |
| Protein Name | Aquaporin-3Aqp-3Aquaglyceroporin-3 |
| Database Links | Reactome: R-HSA-432040Reactome: R-HSA-432047Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Aquaporin-3 antibodyAnti-Aqp-3 antibodyAnti-Aquaglyceroporin-3 antibodyAnti-AQP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
