| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APOC2 (1-101) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APOC2 |
| Gene ID: |
344 |
| Uniprot ID: |
APOC2_HUMAN |
| Immunogen Region: |
1-101 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human APOC2 (NP_000474.2). |
| Immunogen Sequence: |
MGTRLLPALFLVLLVLGFEV QGTQQPQQDEMPSPTFLTQV KESLSSYWESAKTAAQNLYE KTYLPAVDEKLRDLYSKSTA AMSTYTGIFTDQVLSVLKGE E |
| Tissue Specificity | Liver and intestine. |
| Post Translational Modifications | Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. |
| Function | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. |
| Protein Name | Apolipoprotein C-IiApo-CiiApoc-IiApolipoprotein C2 Cleaved Into - Proapolipoprotein C-IiProapoc-Ii |
| Database Links | Reactome: R-HSA-8963888Reactome: R-HSA-8963889Reactome: R-HSA-8963901Reactome: R-HSA-8964058Reactome: R-HSA-9029569Reactome: R-HSA-975634 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Apolipoprotein C-Ii antibodyAnti-Apo-Cii antibodyAnti-Apoc-Ii antibodyAnti-Apolipoprotein C2 Cleaved Into - Proapolipoprotein C-Ii antibodyAnti-Proapoc-Ii antibodyAnti-APOC2 antibodyAnti-APC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
