Anti-APOC2 antibody (1-101) (STJ119761)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APOC2 (1-101) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOC2 |
| Gene ID | 344 |
| Uniprot ID | APOC2_HUMAN |
| Immunogen Region | 1-101 |
| Immunogen Sequence | MGTRLLPALFLVLLVLGFEV QGTQQPQQDEMPSPTFLTQV KESLSSYWESAKTAAQNLYE KTYLPAVDEKLRDLYSKSTA AMSTYTGIFTDQVLSVLKGE E |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human APOC2 (NP_000474.2). |
Additional Info
| Tissue Specificity | Liver and intestine. |
| Post Translational Modifications | Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. |
| Function | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. |
| Protein Name | Apolipoprotein C-IiApo-CiiApoc-IiApolipoprotein C2 Cleaved Into - Proapolipoprotein C-IiProapoc-Ii |
| Database Links | Reactome: R-HSA-8963888Reactome: R-HSA-8963889Reactome: R-HSA-8963901Reactome: R-HSA-8964058Reactome: R-HSA-9029569Reactome: R-HSA-975634 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Apolipoprotein C-Ii antibodyAnti-Apo-Cii antibodyAnti-Apoc-Ii antibodyAnti-Apolipoprotein C2 Cleaved Into - Proapolipoprotein C-Ii antibodyAnti-Proapoc-Ii antibodyAnti-APOC2 antibodyAnti-APC2 antibody |
Information sourced from Uniprot.org