Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-APOA1 (25-267) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | APOA1 |
Gene ID: | 335 |
Uniprot ID: | APOA1_HUMAN |
Immunogen Region: | 25-267 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-267 of human APOA1 (NP_000030.1). |
Immunogen Sequence: | DEPPQSPWDRVKDLATVYVD VLKDSGRDYVSQFEGSALGK QLNLKLLDNWDSVTSTFSKL REQLGPVTQEFWDNLEKETE GLRQEMSKDLEEVKAKVQPY LDDFQKKWQEEMELYRQKVE PLRAELQEGARQKLHELQEK LSPLGEEMRDRARAHVDALR THLAPYSDELRQRLAARLEA LKENGGARLAEYHAKATEHL STLSEKAKPALEDLRQGLLP VLESFKVSFLSALEEYTKK |
Tissue Specificity | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. |
Post Translational Modifications | Glycosylated. Palmitoylated. Phosphorylation sites are present in the extracellular medium. |
Function | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
Protein Name | Apolipoprotein A-I Apo-Ai Apoa-I Apolipoprotein A1 Cleaved Into - Proapolipoprotein A-I Proapoa-I - Truncated Apolipoprotein A-I Apolipoprotein A-I(1-242 |
Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-1369062 Reactome: R-HSA-1989781 Reactome: R-HSA-2168880 Reactome: R-HSA-3000471 Reactome: R-HSA-3000480 Reactome: R-HSA-381426 Reactome: R-HSA-5682113 Reactome: R-HSA-8957275 Reactome: R-HSA-8963888 Reactome: R-HSA-8963896 Reactome: R-HSA-8963901 Reactome: R-HSA-8964011 Reactome: R-HSA-8964058 Reactome: R-HSA-9707616 Reactome: R-HSA-975634 Reactome: R-HSA-977225 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Apolipoprotein A-I antibody Anti-Apo-Ai antibody Anti-Apoa-I antibody Anti-Apolipoprotein A1 Cleaved Into - Proapolipoprotein A-I antibody Anti-Proapoa-I - Truncated Apolipoprotein A-I antibody Anti-Apolipoprotein A-I(1-242 antibody Anti-APOA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance