| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APLP1 (470-649) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APLP1 |
| Gene ID: |
333 |
| Uniprot ID: |
APLP1_HUMAN |
| Immunogen Region: |
470-649 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 470-649 of human APLP1 (NP_005157.1). |
| Immunogen Sequence: |
NPHLAQELRPQIQELLHSEH LGPSELEAPAPGGSSEDKGG LQPPDSKDDTPMTLPKGSTE QDAASPEKEKMNPLEQYERK VNASVPRGFPFHSSEIQRDE LAPAGTGVSRE |
| Tissue Specificity | Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). |
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1Amyloid BetaA4 Precursor-Like Protein 1Amyloid-Like Protein 1AplpAplp-1 Cleaved Into - C30 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinC30: CytoplasmC-Terminally Processed In The Golgi Complex |
| Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 1 antibodyAnti-Amyloid Beta antibodyAnti-A4 Precursor-Like Protein 1 antibodyAnti-Amyloid-Like Protein 1 antibodyAnti-Aplp antibodyAnti-Aplp-1 Cleaved Into - C30 antibodyAnti-APLP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
