Anti-APLP1 antibody (360-440 aa) (STJ96423)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from APLP-1 at the amino acid range 360-440
General Information
| Short Description | Rabbit polyclonal anti-Amyloid beta precursor like protein 1 precursor-like protein 1 (360-440 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APLP1 |
| Gene ID | 333 |
| Uniprot ID | APLP1_HUMAN |
| Immunogen | Synthesized peptide derived from APLP-1 at the amino acid range 360-440 |
| Immunogen Region | 360-440 aa |
| Specificity | APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein. |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1Amyloid BetaA4 Precursor-Like Protein 1Amyloid-Like Protein 1AplpAplp-1 Cleaved Into - C30 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinC30: CytoplasmC-Terminally Processed In The Golgi Complex |
| Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 1 antibodyAnti-Amyloid Beta antibodyAnti-A4 Precursor-Like Protein 1 antibodyAnti-Amyloid-Like Protein 1 antibodyAnti-Aplp antibodyAnti-Aplp-1 Cleaved Into - C30 antibodyAnti-APLP1 antibody |
Information sourced from Uniprot.org