| Short Description : | Rabbit polyclonal APCS (1-223) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | APCS |
| Gene ID: | 325 |
| Uniprot ID: | SAMP_HUMAN |
| Immunogen Region: | 1-223 |
| Immunogen Sequence: | MNKPLLWISVLTSLLEAFAH TDLSGKVFVFPRESVTDHVN LITPLEKPLQNFTLCFRAYS DLSRAYSLFSYNTQGRDNEL LVYKERVGEYSLYIGRHKVT SKVIEKFPAPVHICVSWESS SGIAEFWINGTPLVKKGLRQ GYFVEAQPKIVLGQEQDSYG GKFDRSQSFVGEIGDLYMWD SVLPPENILSAYQGTPLPAN ILDWQALNYEIRGYVIIKPL VWV |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-223 of human APCS (NP_001630.1). |
| Tissue Specificity | Found in serum and urine. |
| Post Translational Modifications | N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected. |
| Function | Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. |
| Protein Name | Serum Amyloid P-ComponentSap9.5s Alpha-1-Glycoprotein Cleaved Into - Serum Amyloid P-Component(1-203 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Serum Amyloid P-Component antibodyAnti-Sap antibodyAnti-9.5s Alpha-1-Glycoprotein Cleaved Into - Serum Amyloid P-Component(1-203 antibodyAnti-APCS antibodyAnti-PTX2 antibody |
Information sourced from Uniprot.org
