| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APBA1 (240-390) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APBA1 |
| Gene ID: |
320 |
| Uniprot ID: |
APBA1_HUMAN |
| Immunogen Region: |
240-390 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human APBA1 (NP_001154.2). |
| Immunogen Sequence: |
ERSDGESDSPEKEAEFAPYP RMDSYEQEEDIDQIVAEVKQ SMSSQSLDKAAEDMPEAEQD LERPPTPAGGRPDSPGLQAP AGQQRAVGPAGGGEAGQRYS KEKRDAISLAIKDIKEAIEE VKTRTIRSPYTPDEPKEPIW VMRQDISPTRD |
| Tissue Specificity | Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen. |
| Function | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. |
| Protein Name | Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1Adapter Protein X11alphaNeuron-Specific X11 ProteinNeuronal Munc18-1-Interacting Protein 1Mint-1 |
| Database Links | Reactome: R-HSA-212676Reactome: R-HSA-6794361Reactome: R-HSA-9609736 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusOnly About 5% Of The Protein Is Located In The NucleusIsoform 2: Golgi Apparatus |
| Alternative Antibody Names | Anti-Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1 antibodyAnti-Adapter Protein X11alpha antibodyAnti-Neuron-Specific X11 Protein antibodyAnti-Neuronal Munc18-1-Interacting Protein 1 antibodyAnti-Mint-1 antibodyAnti-APBA1 antibodyAnti-MINT1 antibodyAnti-X11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
