Anti-APBA1 antibody (240-390) (STJ11100529)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APBA1 (240-390) antibody for use in IHC-P, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APBA1 |
| Gene ID | 320 |
| Uniprot ID | APBA1_HUMAN |
| Immunogen Region | 240-390 |
| Immunogen Sequence | ERSDGESDSPEKEAEFAPYP RMDSYEQEEDIDQIVAEVKQ SMSSQSLDKAAEDMPEAEQD LERPPTPAGGRPDSPGLQAP AGQQRAVGPAGGGEAGQRYS KEKRDAISLAIKDIKEAIEE VKTRTIRSPYTPDEPKEPIW VMRQDISPTRD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 240-390 of human APBA1 (NP_001154.2). |
Additional Info
| Tissue Specificity | Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen. |
| Function | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. |
| Protein Name | Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1Adapter Protein X11alphaNeuron-Specific X11 ProteinNeuronal Munc18-1-Interacting Protein 1Mint-1 |
| Database Links | Reactome: R-HSA-212676Reactome: R-HSA-6794361Reactome: R-HSA-9609736 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusOnly About 5% Of The Protein Is Located In The NucleusIsoform 2: Golgi Apparatus |
| Alternative Antibody Names | Anti-Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1 antibodyAnti-Adapter Protein X11alpha antibodyAnti-Neuron-Specific X11 Protein antibodyAnti-Neuronal Munc18-1-Interacting Protein 1 antibodyAnti-Mint-1 antibodyAnti-APBA1 antibodyAnti-MINT1 antibodyAnti-X11 antibody |
Information sourced from Uniprot.org