Anti-APAF1 antibody (289-338 aa) (STJ91620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human APAF-1-ALT at the amino acid range 289-338
General Information
| Short Description | Rabbit polyclonal anti-Apoptotic protease-activating factor 1 (289-338 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APAF1 |
| Gene ID | 317 |
| Uniprot ID | APAF_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human APAF-1-ALT at the amino acid range 289-338 |
| Immunogen Region | 289-338 aa |
| Specificity | Apaf-1-ALT Polyclonal Antibody detects endogenous levels of Apaf-1-ALT protein. |
Additional Info
| Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. |
| Protein Name | Apoptotic Protease-Activating Factor 1Apaf-1 |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-111459Reactome: R-HSA-111463Reactome: R-HSA-111464Reactome: R-HSA-6798695Reactome: R-HSA-6803207Reactome: R-HSA-8953750Reactome: R-HSA-9627069 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Apoptotic Protease-Activating Factor 1 antibodyAnti-Apaf-1 antibodyAnti-APAF1 antibodyAnti-KIAA0413 antibody |
Information sourced from Uniprot.org