Anti-ANKRD2 antibody (STJA0006944)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ANKRD2
General Information
| Short Description | Rabbit polyclonal anti-Ankyrin repeat domain-containing protein 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKRD2 |
| Gene ID | 26287 |
| Uniprot ID | ANKR2_HUMAN |
| Immunogen | Synthesized peptide derived from human ANKRD2 |
| Specificity | This antibody detects endogenous levels of ANKRD2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. |
| Function | Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. |
| Protein Name | Ankyrin Repeat Domain-Containing Protein 2Skeletal Muscle Ankyrin Repeat ProteinHarpp |
| Database Links | |
| Cellular Localisation | CytoplasmMyofibrilSarcomereI BandCytosolNucleusPml BodyIn The Sarcoplasm Of Differentiated Striated Muscle CellsWhere It Is Cytosolic And Enriched In The I BandIn Nucleus And Pml Bodies Of Proliferating And Undifferentiated MyoblastsAssociates With The Euchromatin In The Nucleus Of Myocytes Upon Muscle Stress |
| Alternative Antibody Names | Anti-Ankyrin Repeat Domain-Containing Protein 2 antibodyAnti-Skeletal Muscle Ankyrin Repeat Protein antibodyAnti-Harpp antibodyAnti-ANKRD2 antibodyAnti-ARPP antibody |
Information sourced from Uniprot.org