| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANGPTL4 (26-170) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANGPTL4 |
| Gene ID: |
51129 |
| Uniprot ID: |
ANGL4_HUMAN |
| Immunogen Region: |
26-170 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-170 of human ANGPTL4 (NP_647475.1). |
| Immunogen Sequence: |
GPVQSKSPRFASWDEMNVLA HGLLQLGQGLREHAERTRSQ LSALERRLSACGSACQGTEG STDLPLAPESRVDPEVLHSL QTQLKAQNSRIQQLFHKVAQ QQRHLEKQHLRIQHLQSQFG LLDHKHLDHEVAKPARRKRL PEMAQ |
| Tissue Specificity | Detected in blood plasma (at protein level). Detected in liver. Detected in white fat tissue and placenta. Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. |
| Post Translational Modifications | N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell. |
| Function | Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein. |
| Protein Name | Angiopoietin-Related Protein 4Angiopoietin-Like Protein 4Hepatic Fibrinogen/Angiopoietin-Related ProteinHfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381340Reactome: R-HSA-8963889Reactome: R-HSA-9762292 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixThe Unprocessed Form Interacts With The Extracellular MatrixThis May Constitute A Dynamic ReservoirA Regulatory Mechanism Of The Bioavailability Of Angptl4 (Probable) |
| Alternative Antibody Names | Anti-Angiopoietin-Related Protein 4 antibodyAnti-Angiopoietin-Like Protein 4 antibodyAnti-Hepatic Fibrinogen/Angiopoietin-Related Protein antibodyAnti-Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain antibodyAnti-ANGPTL4 antibodyAnti-ARP4 antibodyAnti-HFARP antibodyAnti-PGAR antibodyAnti-PP1158 antibodyAnti-PSEC0166 antibodyAnti-UNQ171 antibodyAnti-PRO197 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
