Anti-ANAPC11 antibody (1-84) (STJ117644)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ANAPC11 (1-84) antibody for use in WB, IHC-P, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANAPC11 |
| Gene ID | 51529 |
| Uniprot ID | APC11_HUMAN |
| Immunogen Region | 1-84 |
| Immunogen Sequence | MKVKIKCWNGVATWLWVAND ENCGICRMAFNGCCPDCKVP GDDCPLVWGQCSHCFHMHCI LKWLHAQQVQQHCPMCRQEW KFKE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human ANAPC11 (NP_001002245.1). |
Additional Info
| Tissue Specificity | Expressed at high levels in skeletal muscle and heart.in moderate levels in brain, kidney, and liver.and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Protein Name | Anaphase-Promoting Complex Subunit 11Apc11Cyclosome Subunit 11Hepatocellular Carcinoma-Associated Ring Finger Protein |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 11 antibodyAnti-Apc11 antibodyAnti-Cyclosome Subunit 11 antibodyAnti-Hepatocellular Carcinoma-Associated Ring Finger Protein antibodyAnti-ANAPC11 antibodyAnti-HSPC214 antibody |
Information sourced from Uniprot.org