| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 |
| Gene Symbol: | ALPK1 |
| Gene ID: | 80216 |
| Uniprot ID: | ALPK1_HUMAN |
| Immunogen Region: | 1-473 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-473 of human ALPK1 (NP_079420.3). |
| Immunogen Sequence: | MNNQKVVAVLLQECKQVLDQ LLLEAPDVSEEDKSEDQRCR ALLPSELRTLIQEAKEMKWP FVPEKWQYKQAVGPEDKTNL KDVIGAGLQQLLASLRASIL ARDCAAAAAIVFLVDRFLYG LDVSGKLLQVAKGLHKLQPA TPIAPQVVIRQARISVNSGK LLKAEYILSSLISNNGATGT WLYRNESDKVLVQSVCIQIR GQILQKLGMWYEAAELIWAS IVGYLALPQPDKKGLSTSL |
| Tissue Specificity | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina. |
| Function | Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis. |
| Protein Name | Alpha-Protein Kinase 1 Chromosome 4 Kinase Lymphocyte Alpha-Protein Kinase |
| Database Links | Reactome: R-HSA-445989 Reactome: R-HSA-9645460 |
| Cellular Localisation | Cytoplasm Cytosol Cytoskeleton Spindle Pole Microtubule Organizing Center Centrosome Cell Projection Cilium Localized At The Base Of Primary Cilia |
| Alternative Antibody Names | Anti-Alpha-Protein Kinase 1 antibody Anti-Chromosome 4 Kinase antibody Anti-Lymphocyte Alpha-Protein Kinase antibody Anti-ALPK1 antibody Anti-KIAA1527 antibody Anti-LAK antibody |
Information sourced from Uniprot.org