Anti-ALPK1 antibody (1-473 aa) (STJ11106978)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ALPK1 (1-473 aa) antibody for use in WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000 |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALPK1 |
| Gene ID | 80216 |
| Uniprot ID | ALPK1_HUMAN |
| Immunogen Region | 1-473 aa |
| Immunogen Sequence | MNNQKVVAVLLQECKQVLDQ LLLEAPDVSEEDKSEDQRCR ALLPSELRTLIQEAKEMKWP FVPEKWQYKQAVGPEDKTNL KDVIGAGLQQLLASLRASIL ARDCAAAAAIVFLVDRFLYG LDVSGKLLQVAKGLHKLQPA TPIAPQVVIRQARISVNSGK LLKAEYILSSLISNNGATGT WLYRNESDKVLVQSVCIQIR GQILQKLGMWYEAAELIWAS IVGYLALPQPDKKGLSTSL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-473 of human ALPK1 (NP_079420.3). |
Additional Info
| Tissue Specificity | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina. |
| Function | Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis. |
| Protein Name | Alpha-Protein Kinase 1Chromosome 4 KinaseLymphocyte Alpha-Protein Kinase |
| Database Links | Reactome: R-HSA-445989Reactome: R-HSA-9645460 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonSpindle PoleMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumLocalized At The Base Of Primary Cilia |
| Alternative Antibody Names | Anti-Alpha-Protein Kinase 1 antibodyAnti-Chromosome 4 Kinase antibodyAnti-Lymphocyte Alpha-Protein Kinase antibodyAnti-ALPK1 antibodyAnti-KIAA1527 antibodyAnti-LAK antibody |
Information sourced from Uniprot.org