Anti-alpha-2-macroglobulin antibody (Internal) (STJ73369)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-alpha-2-macroglobulin (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 200kDa band observed in Human Albumin-depleted Serum lysates (calculated MW of 163kDa according to NP_000005.2). The observed molecular weight corresponds to the glycosylated fo |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | A2M |
| Gene ID | 2 |
| Uniprot ID | A2MG_HUMAN |
| Accession Number | NP_000005.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | TSLTVRVNYKDRSP |
Additional Info
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-2-Macroglobulin antibodyAnti-Alpha-2-M antibodyAnti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibodyAnti-A2M antibodyAnti-CPAMD5 antibodyAnti-FWP007 antibody |
Information sourced from Uniprot.org