| Host: |
Rabbit |
| Applications: |
IHC/IF/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNA demethylase ALKBH5 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200WB 1:500-2000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALKBH5 |
| Gene ID: |
54890 |
| Uniprot ID: |
ALKB5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of human ALKBH5 |
| Immunogen: |
Synthesized peptide derived from the human ALKBH5 |
| Function | Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells. |
| Protein Name | Rna Demethylase Alkbh5Alkylated Dna Repair Protein Alkb Homolog 5Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 5 |
| Database Links | Reactome: R-HSA-73943 |
| Cellular Localisation | Nucleus Speckle |
| Alternative Antibody Names | Anti-Rna Demethylase Alkbh5 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 5 antibodyAnti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 5 antibodyAnti-ALKBH5 antibodyAnti-ABH5 antibodyAnti-OFOXD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
