| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALG1 |
| Gene ID: | 56052 |
| Uniprot ID: | ALG1_HUMAN |
| Immunogen Region: | 215-464 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-464 of human ALG1 (NP_061982.3). |
| Immunogen Sequence: | YDKPASFFKETPLDLQHRLF MKLGSMHSPFRARSEPEDPV TERSAFTERDAGSGLVTRLR ERPALLVSSTSWTEDEDFSI LLAALEKFEQLTLDGHNLPS LVCVITGKGPLREYYSRLIH QKHFQHIQVCTPWLEAEDYP LLLGSADLGVCLHTSSSGLD LPMKVVDMFGCCLPVCAVNF KCLHELVKHEENGLVFEDSE ELAAQLQMLFSNFPDPAGKL NQFRKNLRESQQLRWDESW |
| Function | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. |
| Protein Name | Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Asparagine-Linked Glycosylation Protein 1 Homolog Beta-1 -4-Mannosyltransferase Gdp-Man -Glcnac2-Pp-Dolichol Mannosyltransferase Gdp-Mannose-Dolichol Diphosphochitobiose Mannosyltransferase Mannosyltransferase-1 Mt-1 Hmat-1 |
| Database Links | Reactome: R-HSA-446193 Reactome: R-HSA-4549380 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chitobiosyldiphosphodolichol Beta-Mannosyltransferase antibody Anti-Asparagine-Linked Glycosylation Protein 1 Homolog antibody Anti-Beta-1 -4-Mannosyltransferase antibody Anti-Gdp-Man -Glcnac2-Pp-Dolichol Mannosyltransferase antibody Anti-Gdp-Mannose-Dolichol Diphosphochitobiose Mannosyltransferase antibody Anti-Mannosyltransferase-1 antibody Anti-Mt-1 antibody Anti-Hmat-1 antibody Anti-ALG1 antibody Anti-HMAT1 antibody Anti-HMT1 antibody Anti-PSEC0061 antibody Anti-UNQ861 antibody Anti-PRO1870 antibody |
Information sourced from Uniprot.org