| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALG1 |
| Gene ID: |
56052 |
| Uniprot ID: |
ALG1_HUMAN |
| Immunogen Region: |
215-464 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 215-464 of human ALG1 (NP_061982.3). |
| Immunogen Sequence: |
YDKPASFFKETPLDLQHRLF MKLGSMHSPFRARSEPEDPV TERSAFTERDAGSGLVTRLR ERPALLVSSTSWTEDEDFSI LLAALEKFEQLTLDGHNLPS LVCVITGKGPLREYYSRLIH QKHFQHIQVCTPWLEAEDYP LLLGSADLGVCLHTSSSGLD LPMKVVDMFGCCLPVCAVNF KCLHELVKHEENGLVFEDSE ELAAQLQMLFSNFPDPAGKL NQFRKNLRESQQLRWDESW |
| Function | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. |
| Protein Name | Chitobiosyldiphosphodolichol Beta-MannosyltransferaseAsparagine-Linked Glycosylation Protein 1 HomologBeta-1 -4-MannosyltransferaseGdp-Man -Glcnac2-Pp-Dolichol MannosyltransferaseGdp-Mannose-Dolichol Diphosphochitobiose MannosyltransferaseMannosyltransferase-1Mt-1Hmat-1 |
| Database Links | Reactome: R-HSA-446193Reactome: R-HSA-4549380 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chitobiosyldiphosphodolichol Beta-Mannosyltransferase antibodyAnti-Asparagine-Linked Glycosylation Protein 1 Homolog antibodyAnti-Beta-1 -4-Mannosyltransferase antibodyAnti-Gdp-Man -Glcnac2-Pp-Dolichol Mannosyltransferase antibodyAnti-Gdp-Mannose-Dolichol Diphosphochitobiose Mannosyltransferase antibodyAnti-Mannosyltransferase-1 antibodyAnti-Mt-1 antibodyAnti-Hmat-1 antibodyAnti-ALG1 antibodyAnti-HMAT1 antibodyAnti-HMT1 antibodyAnti-PSEC0061 antibodyAnti-UNQ861 antibodyAnti-PRO1870 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
