Anti-ALDOB antibody (1-200) (STJ22585)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ALDOB (1-200) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALDOB |
| Gene ID | 229 |
| Uniprot ID | ALDOB_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MAHRFPALTQEQKKELSEIA QSIVANGKGILAADESVGTM GNRLQRIKVENTEENRRQFR EILFSVDSSINQSIGGVILF HETLYQKDSQGKLFRNILKE KGIVVGIKLDQGGAPLAGTN KETTIQGLDGLSERCAQYKK DGVDFGKWRAVLRIADQCPS SLAIQENANALARYASICQQ NGLVPIVEPEVIPDGDHDLE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ALDOB (NP_000026.2). |
Additional Info
| Function | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check. |
| Protein Name | Fructose-Bisphosphate Aldolase BLiver-Type Aldolase |
| Database Links | Reactome: R-HSA-5657560Reactome: R-HSA-70171Reactome: R-HSA-70263Reactome: R-HSA-70350 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar Satellite |
| Alternative Antibody Names | Anti-Fructose-Bisphosphate Aldolase B antibodyAnti-Liver-Type Aldolase antibodyAnti-ALDOB antibodyAnti-ALDB antibody |
Information sourced from Uniprot.org