| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDH7A1 |
| Gene ID: | 501 |
| Uniprot ID: | AL7A1_HUMAN |
| Immunogen Region: | 430-539 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-539 of human ALDH7A1 (NP_001173.2). |
| Immunogen Sequence: | APILYVFKFKNEEEVFAWNN EVKQGLSSSIFTKDLGRIFR WLGPKGSDCGIVNVNIPTSG AEIGGAFGGEKHTGGGRESG SDAWKQYMRRSTCTINYSKD LPLAQGIKFQ |
| Tissue Specificity | Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue. |
| Function | Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. |
| Protein Name | Alpha-Aminoadipic Semialdehyde Dehydrogenase Alpha-Aasa Dehydrogenase Aldehyde Dehydrogenase Family 7 Member A1 Antiquitin-1 Betaine Aldehyde Dehydrogenase Delta1-Piperideine-6-Carboxylate Dehydrogenase P6c Dehydrogenase |
| Database Links | Reactome: R-HSA-6798163 Reactome: R-HSA-71064 |
| Cellular Localisation | Isoform 2: Cytoplasm Cytosol Nucleus Isoform 1: Mitochondrion |
| Alternative Antibody Names | Anti-Alpha-Aminoadipic Semialdehyde Dehydrogenase antibody Anti-Alpha-Aasa Dehydrogenase antibody Anti-Aldehyde Dehydrogenase Family 7 Member A1 antibody Anti-Antiquitin-1 antibody Anti-Betaine Aldehyde Dehydrogenase antibody Anti-Delta1-Piperideine-6-Carboxylate Dehydrogenase antibody Anti-P6c Dehydrogenase antibody Anti-ALDH7A1 antibody Anti-ATQ1 antibody |
Information sourced from Uniprot.org