Anti-ALAS2 antibody (434-484) (STJA0006585)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HEM0 AA range: 434-484
General Information
| Short Description | Rabbit polyclonal anti-5-aminolevulinate synthase, erythroid-specific, mitochondrial (434-484) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALAS2 |
| Gene ID | 212 |
| Uniprot ID | HEM0_HUMAN |
| Immunogen | Synthesized peptide derived from human HEM0 AA range: 434-484 |
| Immunogen Region | 434-484 |
| Specificity | This antibody detects endogenous levels of human HEM0 |
Additional Info
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Contributes significantly to heme formation during erythropoiesis. Isoform 3: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 75-85% of isoform 1 activity. Isoform 4: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 65-75% of isoform 1 activity. |
| Protein Name | 5-Aminolevulinate Synthase - Erythroid-Specific - MitochondrialAlas-E5-Aminolevulinic Acid Synthase 2Delta-Ala Synthase 2Delta-Aminolevulinate Synthase 2 |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner MembraneIsoform 4: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Erythroid-Specific - Mitochondrial antibodyAnti-Alas-E antibodyAnti-5-Aminolevulinic Acid Synthase 2 antibodyAnti-Delta-Ala Synthase 2 antibodyAnti-Delta-Aminolevulinate Synthase 2 antibodyAnti-ALAS2 antibodyAnti-ALASE antibodyAnti-ASB antibody |
Information sourced from Uniprot.org