| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Contributes significantly to heme formation during erythropoiesis. Isoform 3: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 75-85% of isoform 1 activity. Isoform 4: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 65-75% of isoform 1 activity. |
| Protein Name | 5-Aminolevulinate Synthase - Erythroid-Specific - MitochondrialAlas-E5-Aminolevulinic Acid Synthase 2Delta-Ala Synthase 2Delta-Aminolevulinate Synthase 2 |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner MembraneIsoform 4: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Erythroid-Specific - Mitochondrial antibodyAnti-Alas-E antibodyAnti-5-Aminolevulinic Acid Synthase 2 antibodyAnti-Delta-Ala Synthase 2 antibodyAnti-Delta-Aminolevulinate Synthase 2 antibodyAnti-ALAS2 antibodyAnti-ALASE antibodyAnti-ASB antibody |
Information sourced from Uniprot.org
