| Post Translational Modifications | In normoxia, is hydroxylated at Pro-576, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. Ubiquitinated.in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. |
| Protein Name | 5-Aminolevulinate Synthase - Non-Specific - MitochondrialAlas-H5-Aminolevulinic Acid Synthase 1Delta-Ala Synthase 1Delta-Aminolevulinate Synthase 1 |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Non-Specific - Mitochondrial antibodyAnti-Alas-H antibodyAnti-5-Aminolevulinic Acid Synthase 1 antibodyAnti-Delta-Ala Synthase 1 antibodyAnti-Delta-Aminolevulinate Synthase 1 antibodyAnti-ALAS1 antibodyAnti-ALAS3 antibodyAnti-ALASH antibodyAnti-OK antibodyAnti-SW-cl.121 antibody |
Information sourced from Uniprot.org
