Anti-AKIRIN2 antibody (14-64 aa) (STJ194211)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human AKIR2 at the amino acid range 14-64
General Information
| Short Description | Rabbit polyclonal anti-Akirin-2 (14-64 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AKIRIN2 |
| Gene ID | 55122 |
| Uniprot ID | AKIR2_HUMAN |
| Immunogen | Synthesized peptide derived from the human AKIR2 at the amino acid range 14-64 |
| Immunogen Region | 14-64 aa |
| Specificity | This antibody detects endogenous levels of AKIR2 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Polyubiquitinated. Polyubiquitination is dependent of UBR5 that extends pre-ubiquitinated AKIRIN2. |
| Function | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore. Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development. |
| Protein Name | Akirin-2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmMembranePresent Mainly In The Nuclear FractionAnd At Much Lower Level In The Cytoplasmic And Membrane Fractions |
| Alternative Antibody Names | Anti-Akirin-2 antibodyAnti-AKIRIN2 antibodyAnti-C6orf166 antibody |
Information sourced from Uniprot.org