| Post Translational Modifications | Polyubiquitinated. Polyubiquitination is dependent of UBR5 that extends pre-ubiquitinated AKIRIN2. |
| Function | Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development. Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore. Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development. |
| Protein Name | Akirin-2 |
| Cellular Localisation | NucleusCytoplasmMembranePresent Mainly In The Nuclear FractionAnd At Much Lower Level In The Cytoplasmic And Membrane Fractions |
| Alternative Antibody Names | Anti-Akirin-2 antibodyAnti-AKIRIN2 antibodyAnti-C6orf166 antibody |
Information sourced from Uniprot.org
