| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Type-1 angiotensin II receptor is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:10000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGTR1 |
| Gene ID: | 185 |
| Uniprot ID: | AGTR1_HUMAN |
| Specificity: | This antibody detects endogenous levels of AGTR1. |
| Immunogen: | Synthesized peptide derived from the human AGTR1 Polyclonal |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. |
| Protein Name | Type-1 Angiotensin Ii Receptor At1ar At1br Angiotensin Ii Type-1 Receptor At1 Receptor |
| Database Links | Reactome: R-HSA-375276 Reactome: R-HSA-416476 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Type-1 Angiotensin Ii Receptor antibody Anti-At1ar antibody Anti-At1br antibody Anti-Angiotensin Ii Type-1 Receptor antibody Anti-At1 Receptor antibody Anti-AGTR1 antibody Anti-AGTR1A antibody Anti-AGTR1B antibody Anti-AT2R1 antibody Anti-AT2R1B antibody |
Information sourced from Uniprot.org