Western blot analysis of various lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000

Anti-AGTR1 antibody (STJ99655)

SKU:
STJ99655
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Type-1 angiotensin II receptor is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:10000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AGTR1
Gene ID: 185
Uniprot ID: AGTR1_HUMAN
Specificity: This antibody detects endogenous levels of AGTR1.
Immunogen: Synthesized peptide derived from the human AGTR1 Polyclonal
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated.
Function Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
Protein Name Type-1 Angiotensin Ii Receptor
At1ar
At1br
Angiotensin Ii Type-1 Receptor
At1 Receptor
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Type-1 Angiotensin Ii Receptor antibody
Anti-At1ar antibody
Anti-At1br antibody
Anti-Angiotensin Ii Type-1 Receptor antibody
Anti-At1 Receptor antibody
Anti-AGTR1 antibody
Anti-AGTR1A antibody
Anti-AGTR1B antibody
Anti-AT2R1 antibody
Anti-AT2R1B antibody

Information sourced from Uniprot.org

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