| Function | Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. |
| Protein Name | Cytosolic Carboxypeptidase-Like Protein 5Atp/Gtp-Binding Protein-Like 5Protein Deglutamylase Ccp5 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmCytosolNucleusCytoskeletonSpindleMidbodyMainly CytoplasmicSlight Accumulation In The Nucleus Is ObservedColocalizes With Alpha-Tubulin In The Mitotic Spindle And With Midbody Microtubules In The Intercellular Bridges Formed During Cytokinesis |
| Alternative Antibody Names | Anti-Cytosolic Carboxypeptidase-Like Protein 5 antibodyAnti-Atp/Gtp-Binding Protein-Like 5 antibodyAnti-Protein Deglutamylase Ccp5 antibodyAnti-AGBL5 antibodyAnti-CCP5 antibody |
Information sourced from Uniprot.org
